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Open WellbeingWhat the studies actually measured

Mood, stress and thinking

Folateand Depression

Only one source here so far, and it measured lower depression.

How sure anyone can be

Moderate certainty, level 3 of 4

Further research may change this.

The numbers reported

One source’s range, drawn against its own line of no difference and scaled to its own numbers.

-3.62-2.16-0.69

This range stays on one side of the no-difference line.

Bar the confidence interval — the range the true effect is likely to sit inNotch the number the source reportedLine where there would be no difference at all

One source, newest first

What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.

  • Systematic review, 2021 · 5 studies pooled

    Moderate certainty, level 3 of 4

    Folate as adjunct therapy to SSRI/SNRI for major depressive disorder: Systematic review & meta-analysis.

    Complement Ther Med. 2021;61:102770. doi:10.1016/j.ctim.2021.102770. PMID:34450256.

    Number reported
    -2.16
    Which way it went
    Lower
    Likely range
    -3.62 to -0.69
    Source’s own words
    HAM-D points, mean difference vs SSRI/SNRI monotherapy
    Who was studied
    Adult with major depressive disorder
    Compared with
    SSRI or SNRI monotherapy
    Amount taken
    Not in the abstract
    For how long
    Not in the abstract
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, one step down: imprecision
    1. Starts at High
    2. Imprecision brought it down to Moderatethe abstract does not state how many participants were pooledNot in the abstract
    3. Ends at ModerateOne step down.
    Checked, nothing to step it down for
    risk of bias and indirectness
    Inconsistency
    No high disagreement reported between the 5 studies it pooled

    Imprecision stops at the first check that applies; others may apply too.

    AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.

    Read the abstract on PubMed

What is still missing from these readings

  • One do not say how many people took part.
  • Amount taken — Not in the abstract.
  • For how long — Not in the abstract.

Something nobody wrote down is never a zero and never a guess.

Nothing left on our list for Folate

All eight things on our list for Folate have been read. That is rare here.

Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.

Read next

This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.