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Open WellbeingWhat the studies actually measured

Long-term health and immunity

Ironand Quality of Life Score

Only one source here so far, and it measured higher quality of Life Score.

How sure anyone can be

Moderate certainty, level 3 of 4

Further research may change this.

The numbers reported

One source’s range, drawn against its own line of no difference and scaled to its own numbers.

0.150.51 standardised effect size0.87

This range stays on one side of the no-difference line.

Bar the confidence interval — the range the true effect is likely to sit inNotch the number the source reportedLine where there would be no difference at all

One source, newest first

What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.

  • Systematic review, 2019 · 3 studies pooled · 128 participants

    Moderate certainty, level 3 of 4

    Iron for the treatment of restless legs syndrome.

    Cochrane Database Syst Rev. 2019;1(1):CD007834. doi:10.1002/14651858.CD007834.pub3. PMID:30609006.

    This source later carried a notice: Update of Cochrane Database Syst Rev. 2012 May 16;(5):CD007834. doi: 10.1002/14651858.CD007834.pub2. The number below is exactly as the source gave it.

    Number reported
    0.51 standardised effect size
    Which way it went
    Higher
    Likely range
    0.15 to 0.87
    Source’s own words
    standardised mean difference in continuous quality-of-life scales vs placebo
    Who was studied
    Adult with restless legs syndrome
    Compared with
    placebo
    Amount taken
    Not in the abstract
    For how long
    14 to 112 days
    Disagreement between studies
    I2= 0%
    Kind of record
    Journal article
    How this rating was reachedstarts at High, one step down: imprecision
    1. Starts at High
    2. Imprecision brought it down to Moderate128 participants is below the 400-participant optimal information size floorReported in the abstract
    3. Ends at ModerateOne step down.
    Checked, nothing to step it down for
    risk of bias and indirectness
    Inconsistency
    No high disagreement reported between the 3 studies it pooled

    Imprecision stops at the first check that applies; others may apply too.

    AI review could not confirm it — an AI agent re-read this finding against the saved source and at least one check failed. The batch record names the check and quotes the sentence that caused the doubt. No person read it.

    Read the abstract on PubMed

What is still missing from these readings

  • Amount taken — Not in the abstract.

Something nobody wrote down is never a zero and never a guess.

Still to read for Iron

Nine of the 18 things on our list for Iron have no reading here yet:

  • Bloating Symptom Severity Score
  • Endurance Performance (Time to Exhaustion)
  • Fractional iron absorption
  • Heart rate variability (RMSSD)
  • Hematocrit
  • Serum iron
  • Six-Minute Walk Test Distance
  • Soluble Transferrin Receptor (sTfR)
  • Total Iron Binding Capacity

Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.

Read next

This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.