Joints, muscles and pain
Riboflavin (vitamin B2)and Migraine frequency
Both sources here measured lower migraine frequency.
How sure anyone can be
Moderate certainty, level 3 of 4Further research may change this.
The most certain of the two findings here; each record carries its own.
The numbers reported
- -1.34
- number of migraine attacks, mean difference versus control (the abstract does not state the counting period)
One further source recorded only which way the numbers went, without a number.
None of these sources gave a likely range — the band the real answer probably sits in — so how precise these numbers are is still an open question here.
Two sources, newest first
What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.
Systematic review, 2025
Moderate certainty, level 3 of 4Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials.
Neurol Sci. 2025;46(2):651-670. doi:10.1007/s10072-024-07794-0. PMID:39404918.
- Number reported
- -1.34
- Which way it went
- Lower
- Likely range
- Not in the abstract
- Source’s own words
- number of migraine attacks, mean difference versus control (the abstract does not state the counting period)
- Who was studied
- Adult with migraine
- Compared with
- placebo or control
- Amount taken
- Not in the abstract
- For how long
- Not in the abstract
- Disagreement between studies
- Not in the abstract
- Kind of record
- Journal article
How this rating was reachedstarts at High, one step down: imprecision
- Starts at High
- Imprecision brought it down to Moderatethe abstract reports no confidence interval for the estimateNot in the abstract
- Ends at ModerateOne step down.
- Checked, nothing to step it down for
- risk of bias and indirectness
- Inconsistency
- No disagreement reported, and no count of studies behind it
Imprecision stops at the first check that applies; others may apply too.
AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.
Systematic review, 2022
Very low certainty, level 1 of 4Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis.
Nutr Neurosci. 2022;25(9):1801-1812. doi:10.1080/1028415X.2021.1904542. PMID:33779525.
- Number reported
- Not in the abstract
- Which way it went
- Lower
- Likely range
- Not in the abstract
- Source’s own words
- no pooled mean difference reported in the abstract; significance only (frequency p = .001)
- Who was studied
- Adult with migraine
- Compared with
- placebo or control
- Amount taken
- 400 mg/d vitamin B2
- For how long
- 90 days
- Disagreement between studies
- I2 = 65% for frequency; I2 = 89% for migraine days
- Kind of record
- Journal article
How this rating was reachedstarts at High, 3 steps down: risk of bias, imprecision and inconsistency
- Starts at High
- Risk of bias brought it down to Moderatethe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
- Imprecision brought it down to Lowthe abstract reports no confidence interval for the estimateNot in the abstract
- Inconsistency brought it down to Very lowheterogeneity across pooled studies is high (I² = 89%)Reported in the abstract
- Ends at Very low3 steps down.
- Checked, nothing to step it down for
- indirectness
Imprecision stops at the first check that applies; others may apply too.
AI review could not confirm it — an AI agent re-read this finding against the saved source and at least one check failed. The batch record names the check and quotes the sentence that caused the doubt. No person read it.
What is still missing from these readings
- One give no number at all, only which way it went.
- Two give no likely range, so how precise those numbers are is unknown.
- Two do not say how many people took part.
- Amount taken — One of Two readings: Not in the abstract.
- For how long — One of Two readings: Not in the abstract.
Something nobody wrote down is never a zero and never a guess.
Nothing left on our list for Riboflavin (vitamin B2)
All two things on our list for Riboflavin (vitamin B2) have been read. That is rare here.
Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.
Read next
Riboflavin (vitamin B2)
One other question read for it
Joints, muscles and pain
18 questions read under it
Migraine frequency
Three other ingredients read against it
Alphabetical, and by nothing else.
This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.