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Open WellbeingWhat the studies actually measured

Hormones, thyroid and fertility

Seleniumand Thyroid Peroxidase Antibodies (TPOAb)

Only one source here so far, and it measured lower thyroid Peroxidase Antibodies (TPOAb).

How sure anyone can be

Moderate certainty, level 3 of 4

Further research may change this.

The numbers reported

One source’s range, drawn against its own line of no difference and scaled to its own numbers.

-1.36-0.96 standardised effect size-0.56

This range stays on one side of the no-difference line.

Bar the confidence interval — the range the true effect is likely to sit inNotch the number the source reportedLine where there would be no difference at all

One source, newest first

What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.

  • Systematic review, 2024 · 29 studies pooled · 2,358 participants

    Moderate certainty, level 3 of 4

    Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

    Thyroid. 2024;34(3):295-313. doi:10.1089/thy.2023.0556. PMID:38243784.

    Number reported
    -0.96 standardised effect size
    Which way it went
    Lower
    Likely range
    -1.36 to -0.56
    Source’s own words
    standardized mean difference in TPOAb vs control
    Who was studied
    Adult with hashimoto thyroiditis
    Compared with
    placebo
    Amount taken
    Not in the abstract
    For how long
    Not in the abstract
    Disagreement between studies
    I2 = 90%
    Kind of record
    Journal article
    How this rating was reachedstarts at High, one step down: inconsistency
    1. Starts at High
    2. Inconsistency brought it down to Moderateheterogeneity across pooled studies is high (I² = 90%)Reported in the abstract
    3. Ends at ModerateOne step down.
    Checked, nothing to step it down for
    risk of bias, indirectness and imprecision

    AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.

    Read the abstract on PubMed

What is still missing from these readings

  • Amount taken — Not in the abstract.
  • For how long — Not in the abstract.

Something nobody wrote down is never a zero and never a guess.

Still to read for Selenium

11 of the 20 things on our list for Selenium have no reading here yet:

  • Depression
  • Estimated VO2max
  • Free thyroxine (fT4)
  • Free triiodothyronine (fT3)
  • High-sensitivity CRP
  • HOMA-IR
  • Mood
  • Oxidative stress (F2-isoprostanes)
  • Plasma Selenium
  • Thyroglobulin Antibodies (TgAb)
  • Total sperm motility

Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.

Read next

  • Selenium

    Eight other questions read for it

  • Hormones, thyroid and fertility

    27 questions read under it

  • Thyroid Peroxidase Antibodies (TPOAb)

    No other ingredients read against it

    Alphabetical, and by nothing else.

This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.