Blood sugar and insulin
Silymarinand HOMA-IR
Two sources here, and they say different things: one measured lower HOMA-IR and one found no clear difference.
How sure anyone can be
Moderate certainty, level 3 of 4Further research may change this.
The most certain of the two findings here; each record carries its own.
The numbers reported
One source’s range, drawn against its own line of no difference and scaled to its own numbers.
-4.55-2.29-0.03
This range stays on one side of the no-difference line.
Two sources, newest first
We do not pick between these or average them into one number.
What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.
Systematic review, 2025
Moderate certainty, level 3 of 4Effects of silymarin on insulin resistance and sensitivity: A systematic review and meta-analysis of randomized controlled trials.
Diabetes Res Clin Pract. 2025;220:112008. doi:10.1016/j.diabres.2025.112008. PMID:39855603.
- Number reported
- -2.29
- Which way it went
- Lower
- Likely range
- -4.55 to -0.03
- Source’s own words
- HOMA-IR units, weighted mean difference vs placebo
- Who was studied
- Adult with metabolic disease
- Compared with
- placebo
- Amount taken
- Not in the abstract
- For how long
- 28 days (upper bound: Not in the abstract)
- Disagreement between studies
- Not in the abstract
- Kind of record
- Journal article
How this rating was reachedstarts at High, one step down: imprecision
- Starts at High
- Imprecision brought it down to Moderatethe abstract does not state how many participants were pooledNot in the abstract
- Ends at ModerateOne step down.
- Checked, nothing to step it down for
- risk of bias and indirectness
- Inconsistency
- No disagreement reported, and no count of studies behind it
Imprecision stops at the first check that applies; others may apply too.
AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.
Systematic review, 2024
Moderate certainty, level 3 of 4Effects of silymarin use on liver enzymes and metabolic factors in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis.
Can Liver J. 2024;7(1):40-53. doi:10.3138/canlivj-2023-0021. PMID:38505782.
- Number reported
- Not in the abstract
- Which way it went
- No clear difference
- Likely range
- Not in the abstract
- Source’s own words
- HOMA-IR mean difference vs control (no pooled estimate reported for the null result)
- Who was studied
- Adult with MASLD
- Compared with
- control (comparator arms not detailed in the abstract)
- Amount taken
- Not in the abstract
- For how long
- Not in the abstract
- Disagreement between studies
- Not in the abstract
- Kind of record
- Journal article
How this rating was reachedstarts at High, one step down: imprecision
- Starts at High
- Imprecision brought it down to Moderatethe abstract reports no confidence interval for the estimateNot in the abstract
- Ends at ModerateOne step down.
- Checked, nothing to step it down for
- risk of bias and indirectness
- Inconsistency
- No disagreement reported, and no count of studies behind it
Imprecision stops at the first check that applies; others may apply too.
AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.
What is still missing from these readings
- One give no number at all, only which way it went.
- One gives no likely range, so how precise that number is is unknown.
- Two do not say how many people took part.
- Amount taken — Not in the abstract.
- For how long — One of Two readings: Not in the abstract.
Something nobody wrote down is never a zero and never a guess.
Nothing left on our list for Silymarin
All 11 things on our list for Silymarin have been read. That is rare here.
Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.
Read next
Silymarin
Ten other questions read for it
Blood sugar and insulin
45 questions read under it
HOMA-IR
Eight other ingredients read against it
First six, alphabetical, and by nothing else. The rest are on Blood sugar and insulin.
This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.