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Open WellbeingWhat the studies actually measured

Energy and exercise

Vitamin B12and Fatigue

Only one source here so far, and it found no clear difference in fatigue.

How sure anyone can be

Low certainty, level 2 of 4

Further research is likely to change this.

The numbers reported

No number has been put on this yet. One source recorded only which way the numbers went — for now, that is all we have here.

One source, newest first

What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.

  • Randomised trial, 2018 · 95 participants

    Low certainty, level 2 of 4

    Surplus vitamin B(12) use does not reduce fatigue in patients with Irritable Bowel Syndrome or inflammatory bowel disease: A randomized double-blind placebo-controlled trial.

    Clin Nutr ESPEN. 2018;23:48-53. doi:10.1016/j.clnesp.2017.10.004. PMID:29460813.

    Number reported
    Not in the abstract
    Which way it went
    No clear difference
    Likely range
    Not in the abstract
    Source’s own words
    Checklist Individual Strength subjective-fatigue subscale vs placebo; no significant between-group difference
    Who was studied
    Adult with IBS or ibd and fatigue
    Compared with
    placebo
    Amount taken
    1,000 µg/d
    For how long
    56 days
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, 2 steps down: risk of bias and imprecision
    1. Starts at High
    2. Risk of bias brought it down to Moderatethe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
    3. Imprecision brought it down to Lowthe abstract reports no confidence interval for the estimateNot in the abstract
    4. Ends at Low2 steps down.
    Checked, nothing to step it down for
    indirectness
    Inconsistency
    One study, so there was nothing to disagree

    Imprecision stops at the first check that applies; others may apply too.

    AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.

    Read the abstract on PubMed

What is still missing from these readings

  • No number at all, only which way it went.
  • One gives no likely range, so how precise that number is is unknown.

Something nobody wrote down is never a zero and never a guess.

Still to read for Vitamin B12

Eight of the 16 things on our list for Vitamin B12 have no reading here yet:

  • Brain Atrophy Rate (MRI Volume Loss)
  • Holotranscobalamin (active B12)
  • Methylmalonic acid (MMA)
  • Muscle strength (1-RM)
  • Sleep onset latency
  • Total sleep time
  • Vitamin B12
  • Wake after sleep onset (WASO)

Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.

Read next

This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.