Inflammation and oxidative stress
Lactobacillus rhamnosus GGand Interleukin-8 (IL-8)
Two sources here, and they say different things: one measured lower interleukin-8 (IL-8) and one reported mixed results.
How sure anyone can be
Very low certainty, level 1 of 4Any estimate here is very uncertain.
The most certain of the two findings here; each record carries its own.
The numbers reported
- -66 percent change
- % reduction in IL-8 production by live LGG vs the flagellin-stimulated group
One further source recorded only which way the numbers went, without a number.
None of these sources gave a likely range — the band the real answer probably sits in — so how precise these numbers are is still an open question here.
Two sources, newest first
We do not pick between these or average them into one number.
What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.
Mechanism study, 2008
Very low certainty, level 1 of 4Live and ultraviolet-inactivated Lactobacillus rhamnosus GG decrease flagellin-induced interleukin-8 production in Caco-2 cells.
J Nutr. 2008;138(11):2264-8. doi:10.3945/jn.108.093658. PMID:18936229.
- Number reported
- -66 percent change
- Which way it went
- Lower
- Likely range
- Not in the abstract
- Source’s own words
- % reduction in IL-8 production by live LGG vs the flagellin-stimulated group
- Who was studied
- In vitro human intestinal epithelium
- Compared with
- flagellin-stimulated cells without LGG (500 microg/L challenge)
- Amount taken
- 100,000,000,000 colony-forming units/L LGG pretreatment
- For how long
- Not in the abstract
- Disagreement between studies
- Not in the abstract
- Kind of record
- Journal article
How this rating was reachedstarts at Very low, 3 steps down: risk of bias, indirectness and imprecision
- Starts at Very low
- Risk of bias — already at Very low, the lowest rungthe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
- Indirectness — already at Very low, the lowest rungevidence is human intestinal cell line caco2, not humanReported in the abstract
- Imprecision — already at Very low, the lowest rungthe abstract reports no confidence interval for the estimateNot in the abstract
- Ends at Very low3 steps down.
- Inconsistency
- No disagreement reported, and no count of studies behind it
Imprecision stops at the first check that applies; others may apply too.
AI review could not confirm it — an AI agent re-read this finding against the saved source and at least one check failed. The batch record names the check and quotes the sentence that caused the doubt. No person read it.
Mechanism study, 2005
Very low certainty, level 1 of 4Alive and dead Lactobacillus rhamnosus GG decrease tumor necrosis factor-alpha-induced interleukin-8 production in Caco-2 cells.
J Nutr. 2005;135(7):1752-6. doi:10.1093/jn/135.7.1752. PMID:15987860.
- Number reported
- Not in the abstract
- Which way it went
- Mixed results
- Likely range
- Not in the abstract
- Source’s own words
- IL-8 production by Caco-2 cells (magnitude not reported in the abstract)
- Who was studied
- In vitro human intestinal epithelium
- Compared with
- unstimulated and TNF-alpha-stimulated cells without LGG
- Amount taken
- 10,000 to 10,000,000,000 cfu/L LGG tested range
- For how long
- Not in the abstract
- Disagreement between studies
- Not in the abstract
- Kind of record
- Journal article
How this rating was reachedstarts at Very low, 4 steps down: risk of bias, indirectness, imprecision and inconsistency
- Starts at Very low
- Risk of bias — already at Very low, the lowest rungthe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
- Indirectness — already at Very low, the lowest rungevidence is human intestinal cell line caco2, not humanReported in the abstract
- Imprecision — already at Very low, the lowest rungthe abstract reports no confidence interval for the estimateNot in the abstract
- Inconsistency — already at Very low, the lowest rungpooled studies disagree on the direction of effectReported in the abstract
- Ends at Very low4 steps down.
Imprecision stops at the first check that applies; others may apply too.
AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.
What is still missing from these readings
- One give no number at all, only which way it went.
- Two give no likely range, so how precise those numbers are is unknown.
- Two do not say how many people took part.
- For how long — Not in the abstract.
Something nobody wrote down is never a zero and never a guess.
Nothing left on our list for Lactobacillus rhamnosus GG
All two things on our list for Lactobacillus rhamnosus GG have been read. That is rare here.
Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.
Read next
Lactobacillus rhamnosus GG
One other question read for it
Inflammation and oxidative stress
37 questions read under it
Interleukin-8 (IL-8)
No other ingredients read against it
Alphabetical, and by nothing else.
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