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Open WellbeingWhat the studies actually measured

Cholesterol and blood fats

Silymarinand Total cholesterol

Three sources here, and they say different things: two measured lower total cholesterol and one found no clear difference.

How sure anyone can be

Moderate certainty, level 3 of 4

Further research may change this.

The most certain of the three findings here; each record carries its own.

The numbers reported

One source’s range, drawn against its own line of no difference and scaled to its own numbers.

-1.23-0.85 standardised effect size-0.47

This range stays on one side of the no-difference line.

Bar the confidence interval — the range the true effect is likely to sit inNotch the number the source reportedLine where there would be no difference at all

Three sources, newest first

We do not pick between these or average them into one number.

What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.

  • Systematic review, 2024

    Moderate certainty, level 3 of 4

    Effects of silymarin use on liver enzymes and metabolic factors in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis.

    Can Liver J. 2024;7(1):40-53. doi:10.3138/canlivj-2023-0021. PMID:38505782.

    Number reported
    Not in the abstract
    Which way it went
    No clear difference
    Likely range
    Not in the abstract
    Source’s own words
    total cholesterol mean difference vs control (no pooled estimate reported for the null result)
    Who was studied
    Adult with MASLD
    Compared with
    control (comparator arms not detailed in the abstract)
    Amount taken
    Not in the abstract
    For how long
    Not in the abstract
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, one step down: imprecision
    1. Starts at High
    2. Imprecision brought it down to Moderatethe abstract reports no confidence interval for the estimateNot in the abstract
    3. Ends at ModerateOne step down.
    Checked, nothing to step it down for
    risk of bias and indirectness
    Inconsistency
    No disagreement reported, and no count of studies behind it

    Imprecision stops at the first check that applies; others may apply too.

    AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.

    Read the abstract on PubMed

  • Systematic review, 2024

    Low certainty, level 2 of 4

    Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis.

    Ann Hepatol. 2024;29(2):101174. doi:10.1016/j.aohep.2023.101174. PMID:38579127.

    Number reported
    -0.85 standardised effect size
    Which way it went
    Lower
    Likely range
    -1.23 to -0.47
    Source’s own words
    standardised mean difference in total cholesterol vs control
    Who was studied
    Adult with NAFLD
    Compared with
    control
    Amount taken
    Not in the abstract
    For how long
    Not in the abstract
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, 2 steps down: risk of bias and imprecision
    1. Starts at High
    2. Risk of bias brought it down to Moderatethe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
    3. Imprecision brought it down to Lowthe abstract does not state how many participants were pooledNot in the abstract
    4. Ends at Low2 steps down.
    Checked, nothing to step it down for
    indirectness
    Inconsistency
    No disagreement reported, and no count of studies behind it

    Imprecision stops at the first check that applies; others may apply too.

    AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.

    Read the abstract on PubMed

  • Systematic review, 2024

    Low certainty, level 2 of 4

    Impacts of Supplementation with Silymarin on Cardiovascular Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.

    Antioxidants (Basel). 2024;13(4). doi:10.3390/antiox13040390. PMID:38671838.

    Number reported
    -13.97 mg/dL
    Which way it went
    Lower
    Likely range
    -23.09 to -4.85
    Source’s own words
    mg/dL total cholesterol, weighted mean difference vs untreated control
    Who was studied
    Adult
    Compared with
    untreated counterparts (control groups across 33 trials)
    Amount taken
    Not in the abstract
    For how long
    Not in the abstract
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, 2 steps down: risk of bias and imprecision
    1. Starts at High
    2. Risk of bias brought it down to Moderatethe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
    3. Imprecision brought it down to Lowthe abstract does not state how many participants were pooledNot in the abstract
    4. Ends at Low2 steps down.
    Checked, nothing to step it down for
    indirectness
    Inconsistency
    No disagreement reported, and no count of studies behind it

    Imprecision stops at the first check that applies; others may apply too.

    AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.

    Read the abstract on PubMed

What is still missing from these readings

  • One give no number at all, only which way it went.
  • One gives no likely range, so how precise that number is is unknown.
  • Three do not say how many people took part.
  • Amount taken — Not in the abstract.
  • For how long — Not in the abstract.

Something nobody wrote down is never a zero and never a guess.

Nothing left on our list for Silymarin

All 11 things on our list for Silymarin have been read. That is rare here.

Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.

Read next

This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.