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Open WellbeingWhat the studies actually measured

Blood sugar and insulin

Vitamin K2 (menaquinone-7)and Adiponectin

Only one source here so far, and it measured higher adiponectin.

How sure anyone can be

Low certainty, level 2 of 4

Further research is likely to change this.

The numbers reported

6.1 percent change
% change in plasma adiponectin over 12 months in the MK-7 arm (placebo -0.7%)

None of these sources gave a likely range — the band the real answer probably sits in — so how precise these numbers are is still an open question here.

One source, newest first

What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.

  • Randomised trial, 2021

    Low certainty, level 2 of 4

    Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women: a randomized controlled trial.

    Eur J Clin Nutr. 2021;75(11):1661-1667. doi:10.1038/s41430-021-00884-8. PMID:33664429.

    Number reported
    6.1 percent change
    Which way it went
    Higher
    Likely range
    Not in the abstract
    Source’s own words
    % change in plasma adiponectin over 12 months in the MK-7 arm (placebo -0.7%)
    Who was studied
    Postmenopausal women
    Compared with
    placebo, with both arms on calcium 800 mg and vitamin D 38 microg
    Amount taken
    375 microg/d MK-7
    For how long
    365 days
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, 2 steps down: risk of bias and imprecision
    1. Starts at High
    2. Risk of bias brought it down to Moderatethe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
    3. Imprecision brought it down to Lowthe abstract reports no confidence interval for the estimateNot in the abstract
    4. Ends at Low2 steps down.
    Checked, nothing to step it down for
    indirectness
    Inconsistency
    One study, so there was nothing to disagree

    Imprecision stops at the first check that applies; others may apply too.

    AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.

    Read the abstract on PubMed

What is still missing from these readings

  • One gives no likely range, so how precise that number is is unknown.
  • One do not say how many people took part.

Something nobody wrote down is never a zero and never a guess.

Still to read for Vitamin K2 (menaquinone-7)

One of the nine things on our list for Vitamin K2 (menaquinone-7) has no reading here yet:

  • Serum menaquinone-7 (MK-7)

Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.

Read next

This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.