Skip to the main content
Open WellbeingWhat the studies actually measured

Bone strength

Vitamin K2 (menaquinone-7)and Undercarboxylated osteocalcin (ucOC)

Only one source here so far, and it measured lower undercarboxylated osteocalcin (ucOC).

How sure anyone can be

Low certainty, level 2 of 4

Further research is likely to change this.

The numbers reported

One source’s range, drawn against its own line of no difference and scaled to its own numbers.

-75.6-70.3 percent change-63.8

This range stays on one side of the no-difference line.

Bar the confidence interval — the range the true effect is likely to sit inNotch the number the source reportedLine where there would be no difference at all

One source, newest first

What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.

  • Randomised trial, 2021

    Low certainty, level 2 of 4

    Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women: a randomized controlled trial.

    Eur J Clin Nutr. 2021;75(11):1661-1667. doi:10.1038/s41430-021-00884-8. PMID:33664429.

    Number reported
    -70.3 percent change
    Which way it went
    Lower
    Likely range
    -75.6 to -63.8
    Source’s own words
    % change in serum undercarboxylated osteocalcin over 12 months in the MK-7 arm (placebo -7.2%)
    Who was studied
    Postmenopausal women
    Compared with
    placebo, with both arms on calcium 800 mg and vitamin D 38 microg
    Amount taken
    375 microg/d MK-7
    For how long
    365 days
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, 2 steps down: risk of bias and imprecision
    1. Starts at High
    2. Risk of bias brought it down to Moderatethe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
    3. Imprecision brought it down to Lowthe abstract does not state how many participants were pooledNot in the abstract
    4. Ends at Low2 steps down.
    Checked, nothing to step it down for
    indirectness
    Inconsistency
    One study, so there was nothing to disagree

    Imprecision stops at the first check that applies; others may apply too.

    AI review could not confirm it — an AI agent re-read this finding against the saved source and at least one check failed. The batch record names the check and quotes the sentence that caused the doubt. No person read it.

    Read the abstract on PubMed

What is still missing from these readings

  • One do not say how many people took part.

Something nobody wrote down is never a zero and never a guess.

Still to read for Vitamin K2 (menaquinone-7)

One of the nine things on our list for Vitamin K2 (menaquinone-7) has no reading here yet:

  • Serum menaquinone-7 (MK-7)

Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.

Read next

  • Vitamin K2 (menaquinone-7)

    Seven other questions read for it

  • Bone strength

    Ten questions read under it

  • Undercarboxylated osteocalcin (ucOC)

    No other ingredients read against it

    Alphabetical, and by nothing else.

This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.