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Open WellbeingWhat the studies actually measured

Inflammation and oxidative stress

Curcuminand High-sensitivity CRP

Both sources here measured lower high-sensitivity CRP.

How sure anyone can be

Moderate certainty, level 3 of 4

Further research may change this.

The most certain of the two findings here; each record carries its own.

The numbers reported

One source’s range, drawn against its own line of no difference and scaled to its own numbers.

-1.2-0.65 standardised effect size-0.1

This range stays on one side of the no-difference line.

Bar the confidence interval — the range the true effect is likely to sit inNotch the number the source reportedLine where there would be no difference at all

Two sources, newest first

What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. Some of these ratings came from a fixed rule with nobody checking them by hand, and some from a person. Each working below says which.

  • Systematic review, 2023

    Low certainty, level 2 of 4

    Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.

    Cytokine. 2023;164:156144. doi:10.1016/j.cyto.2023.156144. PMID:36804260.

    Number reported
    -0.58 mg/L
    Which way it went
    Lower
    Likely range
    -0.74 to -0.41
    Source’s own words
    mg/L CRP weighted mean difference vs control
    Who was studied
    Adult
    Compared with
    control
    Amount taken
    Not in the abstract
    For how long
    Not in the abstract
    Disagreement between studies
    Not in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, 2 steps down: indirectness and imprecision
    1. Starts at High
    2. Indirectness brought it down to Moderatethe outcome measured is a proxy for the target outcomeReported in the abstract
    3. Imprecision brought it down to Lowthe abstract does not state how many participants were pooledNot in the abstract
    4. Ends at Low2 steps down.
    Checked, nothing to step it down for
    risk of bias
    Inconsistency
    No disagreement reported, and no count of studies behind it

    Imprecision stops at the first check that applies; others may apply too.

    AI review could not confirm it — an AI agent re-read this finding against the saved source and at least one check failed. The batch record names the check and quotes the sentence that caused the doubt. No person read it.

    Read the abstract on PubMed

  • Systematic review, 2019

    Moderate certainty, level 3 of 4

    The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.

    Phytother Res. 2019. doi:10.1002/ptr.6226. PMID:30402990.

    Number reported
    -0.65 standardised effect size
    Which way it went
    Lower
    Likely range
    -1.2 to -0.1
    Source’s own words
    standardised effect size (standardized mean difference), hs-CRP vs control
    Who was studied
    Adult
    Compared with
    placebo or control
    Amount taken
    Not in the abstract
    For how long
    Not in the abstract
    Disagreement between studies
    Not in the abstract
    Kind of record
    Systematic review and meta-analysis
    How this rating was reachedstarts at High, one step down: imprecision
    1. Starts at High
    2. Imprecision brought it down to ModerateThe reason for this step is not on record here.
    3. Ends at ModerateOne step down.
    Not written down for this rating
    risk of bias, indirectness and inconsistency

    Imprecision stops at the first check that applies; others may apply too.

    Published before the signing gate; not yet re-verified.

    Read the abstract on PubMed

What is still missing from these readings

  • Two do not say how many people took part.
  • Amount taken — Not in the abstract.
  • For how long — Not in the abstract.

Something nobody wrote down is never a zero and never a guess.

Still to read for Curcumin

Four of the 22 things on our list for Curcumin have no reading here yet:

  • Fasting insulin
  • Type 2 Diabetes Incidence
  • Ulcerative Colitis Disease Activity Index
  • WOMAC Physical Function Subscale

Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.

Read next

This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.