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Open WellbeingWhat the studies actually measured

Heart and blood pressure

Magnesiumand Systolic blood pressure

Both sources here measured lower systolic blood pressure.

How sure anyone can be

Low certainty, level 2 of 4

Further research is likely to change this.

The most certain of the two findings here; each record carries its own.

The numbers reported

One source’s range, drawn against its own line of no difference and scaled to its own numbers.

-4.32-2.81 mmHg-1.29

This range stays on one side of the no-difference line.

Bar the confidence interval — the range the true effect is likely to sit inNotch the number the source reportedLine where there would be no difference at all

Two sources, newest first

What we read is the published abstract, not the full paper, so a blank below may still be printed in the paper itself. A fixed rule worked this out from the source’s own fields. Nobody checked this rating by hand.

  • Systematic review, 2025

    Low certainty, level 2 of 4

    Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    Hypertension. 2025;82(11):1844-1856. doi:10.1161/HYPERTENSIONAHA.125.25129. PMID:41000008.

    Number reported
    -2.81 mmHg
    Which way it went
    Lower
    Likely range
    -4.32 to -1.29
    Source’s own words
    mm Hg systolic BP mean difference vs placebo
    Who was studied
    Adult
    Compared with
    placebo
    Amount taken
    82.3 to 637 mg/d elemental magnesium
    For how long
    28 days (upper bound: Not in the abstract)
    Disagreement between studies
    High heterogeneity reported across studies; no I2 value given in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, 2 steps down: risk of bias and imprecision
    1. Starts at High
    2. Risk of bias brought it down to Moderatethe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
    3. Imprecision brought it down to Lowthe abstract does not state how many participants were pooledNot in the abstract
    4. Ends at Low2 steps down.
    Checked, nothing to step it down for
    indirectness
    Inconsistency
    No disagreement reported, and no count of studies behind it

    Imprecision stops at the first check that applies; others may apply too.

    AI review could not confirm it — an AI agent re-read this finding against the saved source and at least one check failed. The batch record names the check and quotes the sentence that caused the doubt. No person read it.

    Read the abstract on PubMed

  • Systematic review, 2016

    Low certainty, level 2 of 4

    Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials.

    Hypertension. 2016;68(2):324-33. doi:10.1161/HYPERTENSIONAHA.116.07664. PMID:27402922.

    Number reported
    -2 mmHg
    Which way it went
    Lower
    Likely range
    -3.58 to -0.43
    Source’s own words
    mm Hg systolic BP mean difference vs placebo
    Who was studied
    Adult
    Compared with
    placebo
    Amount taken
    368 mg/d elemental magnesium (median dose) (upper bound: Not in the abstract)
    For how long
    91 days (upper bound: Not in the abstract)
    Disagreement between studies
    Residual heterogeneity may still exist after quality and dropout stratification; no I2 value given in the abstract
    Kind of record
    Journal article
    How this rating was reachedstarts at High, 2 steps down: risk of bias and imprecision
    1. Starts at High
    2. Risk of bias brought it down to Moderatethe abstract reports no risk-of-bias or quality appraisal, so study limitations cannot be ruled outNot in the abstract
    3. Imprecision brought it down to Lowthe abstract does not state how many participants were pooledNot in the abstract
    4. Ends at Low2 steps down.
    Checked, nothing to step it down for
    indirectness
    Inconsistency
    No disagreement reported, and no count of studies behind it

    Imprecision stops at the first check that applies; others may apply too.

    AI-reviewed & signed — an AI agent re-read this finding against the saved source and checked that the quote, the numbers, the units and the direction match it. No person read it. The owner authorised the agent to sign the batch with the owner's key, and every build rechecks that signature against these exact bytes.

    Read the abstract on PubMed

What is still missing from these readings

  • Two do not say how many people took part.

Something nobody wrote down is never a zero and never a guess.

Still to read for Magnesium

11 of the 21 things on our list for Magnesium have no reading here yet:

  • Atrial fibrillation incidence
  • Bone mineral density
  • Cognitive performance
  • Depression
  • Fasting insulin
  • Generalized Anxiety Disorder-7 (GAD-7)
  • Hemoglobin A1c
  • Insomnia Severity Index
  • Patient Health Questionnaire-9 (PHQ-9)
  • Sleep efficiency
  • Total testosterone

Still to read means nobody here has got to it, not that it was tried and did nothing or that no research exists. A pairing on no list is not a gap: we never set out to read it.

Read next

This is a library, not advice. No recommendation, no dose, no diagnosis, no ranking. We never ask about your symptoms, and nothing here is tailored to you.